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Q&A ViewAttendees 6

Medical, Urban, and Veterinary Entomology

10-Minute Paper

MUVE: Urban Entomology and Stored Product Pests

Overexpression of cytochrome P450 genes associated with pyrethroid-resistant German cockroaches (Blattodea: Ectobiidae )

Sunday, October 31, 2021
2:30 PM – 2:42 PM MT
Location: Colorado Convention Center, Meeting Room 210-212
In-Person

    Presenting Author(s)

  • Shu-Ping Tseng

    Post doc
    University of California
    Riverside, California

    • Co-Author(s)

  • Shao-Hung Lee

    PhD Student
    University of California
    Riverside, California

  • Chow-Yang Lee, BCE

    Professor & Endowed Presidential Chair in Urban Entomology
    University of California
    Riverside, California

Although cytochrome P450-mediated resistance has been found in many insect pests, the role of overexpressed P450 genes in insecticide resistant German cockroaches, Blattella germanica (L.), remains poorly understood. In this study, we collected four pyrethroid-resistant strains (CDR, RG386, Ryan, and WM) from low-income housing in California, and the four strains have higher concentrations of cytochrome P450 associated protein than an insecticide susceptible strain (UCR). We proceeded to examine the expression of 4 CYP genes (CYP4G19, CYP6J1, CYP6K1, and CYP4C21) encoding P450 enzymes in resistant and susceptible strains using quantitative RT-PCR. CYP6K1 was significantly (P < 0.05) overexpressed in the four resistant strains when compared with the susceptible strain. Although we have yet to establish the functional role of each of these genes, our results suggest that overexpression of CYP6K1 might contribute towards pyrethroid resistance in the pyrethroid-resistant strains from California.